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KMID : 0380620190510020160
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Korean Journal of Food Science and Technology
2019 Volume.51 No. 2 p.160 ~ p.168
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Double-processed ginseng berry extracts enhance learning and memory in an Aβ42-induced Alzheimer’s mouse model
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Jang Su-Kil
Ahn Jeong-Won
Jo Bo-Ram
Kim Seo-Jin
Sung Eun-Ah
Lee Do-Ik
Park Hee-Yong
Jin Deuk-Hee
Joo Seong-Soo
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Abstract
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This study aimed to determine whether double-processed ginseng berry extract (PGBC) could improve learning and memory in an Aa42-induced Alzheimer’s mouse model. Passive avoidance test (PAT) and Morris water-maze test (MWMT) were performed after mice were treated with PGBC, followed by acetylcholine (ACh) measurement and glial fibrillary acidic protein (GFAP) detection for brain damage. Furthermore, acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression were analyzed using Ellman’s and qPCR assays, respectively. Results demonstrated that PGBC contained a high amount of ginsenosides (Re, Rd, and Rg3), which are responsible for the clearance of Aa42. They also helped to significantly improve PAT and MWMT performance in the Aa42-induced Alzheimer’s mouse model when compared to the normal group. Interestingly, ACh and ChAT were remarkably upregulated and AChE activities were significantly inhibited, suggesting PGBC to be a palliative adjuvant for treating Alzheimer’s disease. Altogether, PGBC was found to play a positive role in improving cognitive abilities. Thus, it could be a new alternative solution for alleviating Alzheimer’s disease symptoms.
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KEYWORD
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processed ginseng berry extract, passive avoidance test, Morris water-maze test, acetylcholine, choline, acetyltransferase
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